卢国栋

原发性肝癌的基础和转化研究：

我们课题组重点研究糖脂代谢对肝癌细胞生长和死亡的影响，尤其是在体外葡萄糖缺乏（体内做肝动脉栓塞术导致的缺血）的条件下。我们研究的分子机理聚焦在脂肪代谢，自噬和线粒体稳态，以及激活铁自噬和溶酶体活性，从而促进肿瘤细胞铁死亡和相关药理学应用。

线虫模式生物的药理学和毒理学研究：

我们课题组的研究重点在于通过衰老模式生物线虫的研究，来识别和评价促衰老毒物和老龄化易感毒物，并进一步探索衰老机制和预防措施。

方向1. 原发性肝癌的基础和转化研究

1. Feng J.  et al. The Prognostic Role of ACSL4 in Postoperative Adjuvant TACE-treated HCC: Implications for Therapeutic Response and Mechanistic Insights. Journal of Experimental & Clinical Cancer Research. 2024 Nov 19;43(1):306. doi: 10.1186/s13046-024-03222-5.（最后通讯）

2. Feng J, et al. Pharmacological approaches for targeting lysosomes to induce ferroptotic cell death in cancer. Cancer Letters. 2024 Apr 10;587:216728. doi: 10.1016/j.canlet.2024.216728.（最后通讯）
3. Li XY, et al. Andrographolide causes p53-independent HCC cell death through p62 accumulation and impaired DNA damage repair. Phytomedicine. 2023 Dec;121:155089. doi: 10.1016/j.phymed.2023.155089.（共同通讯)
4. Zhou J, et al. Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy. Experimental and Molecular Medicine. 2022 Nov;54(11): 2007-2021.（最后通讯）
5. Zhou J, et al. Full-coverage regulations of autophagy by ROS: from induction to maturation. Autophagy. 2022 Jun;18(6): 1240-1255.（最后通讯）
6. Wang ZX, et al. Quercetin induces p53-indendent cancer cell death through TFEB-mediated lysosome activation and ROS-dependent ferroptosis. British Journal of Pharmacology. 2021 Mar;178(5):1133-1148. （共同通讯)
7. Li ZJ, et al. Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma. Acta Pharmacologica Sinica. 2021 Feb; 42(2):301-310. （最后通讯）
8. Feng J, et al. ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma. Acta Pharmacologica Sinica. 2021 Jan; 42(1): 160-170. （最后通讯）

方向2. 线虫模式生物的药理学和毒理学研究

1. Yu ZZ, et al. A Mechanistic Analysis of Metformin’s Biphasic Effects on Lifespan and Healthspan in C. elegans: Elixir in Youth. Mechanisms of Ageing and Development. 2024.（最后通讯）
2. Tu JJ, et al. Differential impacts of non-steroidal anti-inflammatory drugs on lifespan and healthspan in aged Caenorhabditis elegans. Journal of Applied Toxicology. 2024 Jun 5. doi: 10.1002/jat.4655.（最后通讯）

Contact Information

Email: lugd@fudan.edu.cn. ORCID: 0000-0001-6056-3196.

Research Interests and Publications

Primary Liver Caner: Basic and Translational Studies

Our team focuses on the effects of glucose and lipid metabolism on the growth and death of liver cancer cells, particularly under conditions of glucose deprivation in vitro or treatment with transarterial embolization in clinical settings. Our investigations center on the molecular mechanisms involved in lipid metabolism, autophagy, and mitochondrial homeostasis, and how to pharmacologically activate ferrotinophagy to promote ferroptosis in tumor cells.

1. 1. Feng J.  et al. The Prognostic Role of ACSL4 in Postoperative Adjuvant TACE-treated HCC: Implications for Therapeutic Response and Mechanistic Insights. Journal of Experimental & Clinical Cancer Research. 2024 Nov 19;43(1):306. doi: 10.1186/s13046-024-03222-5.

   2. Feng J, et al. Pharmacological approaches for targeting lysosomes to induce ferroptotic cell death in cancer. Cancer Letters. 2024 Apr 10;587:216728. doi: 10.1016/j.canlet.2024.216728.
   3. Li XY, et al. Andrographolide causes p53-independent HCC cell death through p62 accumulation and impaired DNA damage repair. Phytomedicine. 2023 Dec;121:155089. doi: 10.1016/j.phymed.2023.155089.
   4. Zhou J, et al. Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy. Experimental and Molecular Medicine. 2022 Nov;54(11): 2007-2021.
   5. Zhou J, et al. Full-coverage regulations of autophagy by ROS: from induction to maturation. Autophagy. 2022 Jun;18(6): 1240-1255.
   6. Wang ZX, et al. Quercetin induces p53-indendent cancer cell death through TFEB-mediated lysosome activation and ROS-dependent ferroptosis. British Journal of Pharmacology. 2021 Mar;178(5):1133-1148. 
   7. Li ZJ, et al. Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma. Acta Pharmacologica Sinica. 2021 Feb; 42(2):301-310.
   8. Feng J, et al. ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma. Acta Pharmacologica Sinica. 2021 Jan; 42(1): 160-170. 

Pharmacological and Toxicological Studies Using C. elegans as a Model Organism: 

Our team emphasizes the use of the model organism Caenorhabditis elegans to identify and evaluate pro-aging toxins and aging-susceptible pollutants. This work further explores the mechanisms of aging and potential preventive measures.

1. Yu ZZ, et al. A Mechanistic Analysis of Metformin’s Biphasic Effects on Lifespan and Healthspan in C. elegans: Elixir in Youth. Mechanisms of Ageing and Development. 2024.
2. Tu JJ, et al. Differential impacts of non-steroidal anti-inflammatory drugs on lifespan and healthspan in aged Caenorhabditis elegans. Journal of Applied Toxicology. 2024 Jun 5. doi: 10.1002/jat.4655.