张若昕

  致力于肿瘤分子流行病学研究，聚焦肺癌和消化系统肿瘤的生物标志物发掘及其致病机制研究。综合运用全基因组关联分析、多组学技术及生物信息学方法，系统识别与肿瘤发生发展相关的生物标志物；进一步通过分子生物学实验，验证其在肿瘤病因学中的生物学功能；并依托前瞻性人群队列，解析遗传因素与环境暴露在肿瘤等慢性疾病发生中的交互作用。主持的科研项目包括国自然青年科学基金、上海市自然科学基金、上海市公共卫生体系建设三年行动计划优秀青年人才，广西重点实验室开放课题。担任多个杂志的审稿人，并于2019年获得由美国抗癌协会和亚洲癌症基金颁发的青年学者奖。科研成果发表在Advanced Science, International Journal of Cancer, Cancer Biology & Medicine, npj Precision Medicine 等多个国际期刊上。

  My research field is molecular epidemiology of cancer, with a focus on the discovery of biomarkers for lung cancer and gastrointestinal cancers and their biological mechanisms. This includes comprehensive application of genome-wide association studies, multi-omics and bioinformatics methods to systematically identify biomarkers associated with cancer onset and progression. Their biological functions in cancer etiology are validated through molecular biology experiments. We are also interested in the interactions between genetic factors and environmental exposures in the development of cancer and other chronic diseases. Our research projects include the National Natural Science Foundation of China, the Shanghai Natural Science Foundation, the Shanghai Three-Year Action Plan for Public Health System Construction (Outstanding Young Talent Program), and an Open Project from the Guangxi Key Laboratory of Education Bureau. Serving as a reviewer for multiple academic journals, the investigator received the Young Investigator Award in 2019 from the American Association for Cancer Research and the Asian Cancer Research Foundation. Our research has been published in several international journals, including Advanced Science, International Journal of Cancer, Cancer Biology & Medicine, and npj Precision Medicine.

研究生课程《分子流行病学》、《肿瘤流行病学》、《临床科研设计与数据分析》、《公共卫生生物信息学》、《遗传流行病学》。本科生课程包括：《预防医学II MBBS》、《流行病学常识与解读》。

2019.06—至今          青年副研究员   复旦大学公共卫生学院  流行病学教研室

2016.01—2019.05   博士后         复旦大学附属肿瘤医院 肿瘤研究所 

2018.07—2018.08   访问学者     美国杜克大学 肿瘤研究中心

2011.09—2015.12   分子医学和遗传学博士 临床药理学系  英国伦敦玛丽女王大学巴兹医学院威廉哈维研究所 

2025.08—至今 肿瘤流行病学专业委员会委员

2024.08 —至今  中华预防医学会会员

2020.10—至今    中国抗癌协会会员

2021.12—2024.12   《肿瘤》杂志青年编委。

中美抗癌协会亚洲癌症研究基金会的USCACA-AFCR青年学者奖

1. Cheng, Q. Hu, Y. Wang, W. Nie, H. Lu, B. Zhang, G. Zhao, S. Ding, F. Pan, Y. Shen, R. Zhong^#, R. Zhang^#. Cis-regulation of an m6A eraser by an insertion variant associated with survival of patients with non-small cell lung carcinoma. Advanced Science. (2025) 12(5):e2407652. doi: 10.1002/advs.202407652. (IF=14.7, Q1)
2. M. Cai, R. Xia, Z. Wang, R. Zhang^#, W. Xu^#. National prevention programs and their effects on gastric cancer Incidence and mortality in East Asian countries. Cancer Biology & Medicine. (2025) 20;22(5):488–495. doi: 10.20892/j.issn.2095-3941.2024.0561. (IF=5.9, Q1)
3. J. Zheng, X. Wang, J. Li, Y. Wu, J. Chang, J. Xin, M. Wang, T. Wang, Q. Wei, M. Wang^#, R. Zhang^#. Rare variants confer shared susceptibility to gastrointestinal tract cancer risk. Frontiers in Oncology. (2023) 6:13:1161639. doi: 10.3389/fonc.2023.1161639.
4. Y. Bai, J. Zheng, L. Cheng, Q. Liu, G. Zhao, J. Li, Y. Gu, W. Xu, M. Wang, Q. Wei, R. Zhang^#. Potentially functional genetic variants of VAV2 and PSMA4 in the immune-activation pathway and non-small cell lung cancer. Journal of Gene Medicine. (2022) 24(10):e3447. doi: 10.1002/jgm.3447

5.  Yang*, H. Liu*, R. Zhang*, J. A. Freedman, Y Han, R. J. Hung, Y. Brhane, J. McLaughlin, P. Brennan, H.      Bickeboeller, A. Rosenberger, R. S. Houlston, N. E. Caporaso, M. T. Landi, I. Brueske, A. Risch, D. C. Christiani, C. I. Amos, X. Chen, S. R. Patierno^#, Q. Wei^#. Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk: Results from the TRICL-ILCCO and OncoArray projects. npj Precision Oncology. (2022) 6(1):48. doi: 10.1038/s41698-022-00281-9. (IF=7.7, Q1)

6. R. Zhang, J. Pei, Y. Wang, L. Wang, Y. Yeerjiang, H. Gao, W. Xu^#. COVID‑19 outbreak improves attractiveness of medical careers in Chinese senior high school students. BMC Medical Education. (2022) 22(1):241. doi: 10.1186/s12909-022-03309-7.
7. L. Cheng*, Q. Liu*, M. Wang, Y. Gu, J. Wang, Q. Wei^#, R. Zhang^#. Genetic variants in the human leukocyte antigen region and survival of Chinese patients with non-small-cell lung carcinoma. Carcinogenesis. (2020) 24;41(9):1203-1212. doi: 10.1093/carcin/bgaa066
8. J. Dai*, J. Lv*, M. Zhu*, Y. Wang*, N. Qin*, H. Ma*, Y. He*, R. Zhang*, T. Wen, J. Fan, T. Wang, H. Zheng, Q. Sun, L. Wang, M. Huang, Z. Ge, C. Yu, Y. Guo, T. Wang, J. Wang, L. Xu, W. Wu, L. Chen, Z. Bian, R. Walters, I. Millwood, X. Li, X. Wang, R. Hung, H. Chen, M. Wang, C. Wang, Y. Jiang, K. Chen, Z. Chen, G. Jin, T. Wu, D. Lin, Z. Hu^#, C. Amos^#, C. Wu^#, Q. Wei^#, W. Jia^#, L. Li^#, HB Shen^#. Risk loci identification and polygenic risk score in prediction of lung cancer: a large-scale prospective cohort study in Chinese. The Lancet Respiratory Medicine. (2019) 7(10):881-891. doi: 10.1016/S2213-2600(19)30144-4.

1. 2025.07—2028.06 上海市自然科学基金 | 上海市科学技术委员会                        在研   20万

“基于多组学整合的早发胃癌易感性生物标志物关联及机制研究”

2. 2021.09—2025.12 复旦大学义乌研究院 “胃癌遗传易感性生物标志物研究”     在研  100万

3. 2020.01—2022.12 国家自然科学基金青年科学基金                                        已结题  20.5万

“XPF基因遗传变异对非小细胞肺癌铂类化疗毒性的影响及其功能研究 ”

4.2020.07—2022.06 上海市公共卫生体系建设三年行动计划优秀青年人才计划 | 上海市卫健委 

“肝癌易感性遗传变异的功能研究和疾病预测模型构建”                                  已结题  21.18万

5. 2020.09—2022.08 广西教育部重点实验室开放课题                                            已结题  7万

“Hedgehog 信号通路基因遗传变异与肝细胞癌预后的关系”