徐珂琳

方法：充分降维方法；网络分析；纵向数据分析

应用：慢性病流行病学及统计建模；多组学数据分析

本科生：卫生统计方法（一）、卫生统计方法（二）、卫生统计学B、卫生统计学C

研究生：医学统计方法

工作经历

• 2024年 至今 复旦大学公共卫生学院 生物统计教研室 副教授
• 2019年~2023年 复旦大学公共卫生学院 生物统计教研室 青年副研究员
• 2017年~2019年 复旦大学大数据学院、遗传与发育协同创新中心 博士后

教育经历

• 2010年~2016年 复旦大学生命科学学院 生物信息学博士
• 2014年~2015年 美国休斯敦健康科学中心生物统计系 国家公派联合培养博士生
• 2006年~2010年  山东大学数学学院国家基地班 统计学学士

1. Kelin Xu, Wensheng Guo*, Momiao Xiong, Liping Zhu, Li Jin. An Estimating Equation Approach to Dimension Reduction for Longitudinal Data. Biometrika, 2016, 103(1): 189-203.
2. Kelin Xu; Liping Zhu*; Jianqing Fan. Distributed sufficient dimension reduction for heterogeneous massive data. Statistica Sinica, 2022, 32:2455-2476
3. Kelin Xu#, Yingzhe Wang#, Yanfeng Jiang, Yawen Wang, Peixi Li, Heyang Lu, Chen Suo, Ziyu Yuan, Qi Yang, Qiang Dong, Li Jin, Mei Cui*, Xingdong Chen*. Analysis of gait pattern related to cerebral small vessel disease using wearable sensors. Computer Methods and Programs in Biomedicine, 2024, 250:108162.
4. Xinming Xu#, Qingying Feng#, Tao Zhang#, Yunlong Gao#, Qu Cheng, Wanqiu Zhang, Qinglong Wu, Ke Xu, Yucan Li, Nhu Nguyen, Diana H. Taft, David A. Mills, Danielle G. Lemay, Weiyun Zhu, Shengyong Mao, Anyun Zhang*, Kelin Xu*, Jinxin Liu*. Infant age inversely correlates with gut carriage of resistance genes, reflecting modifications in microbial carbohydrate metabolism during early life. iMeta, 2024, 3(2):e169.
5. Yi Zheng, Jincheng Li, Yucan Li, Jiacheng Wang, Chen Suo, Yanfeng Jiang, Li Jin, Kelin Xu*, Xingdong Chen*.Plasma proteomic profiles reveal proteins and three characteristic patterns associated with osteoporosis: A prospective cohort study. Journal of Advanced Research, 2024: S2090-1232(24)00474-0.

• 国家自然科学基金青年科学基金项目，基于充分降维方法的复杂疾病多层次调控模型研究，2024.01-2026.12，在研，主持。
• 上海市2023年度“科技创新行动计划”自然科学基金面上项目，基于多尺度表型数据的生物学年龄估计方法研究，2023.04-2026.03，在研，主持。
• 科技创新 2030-“脑科学与类脑研究”重大项目，中国HEAD东部社区队列建设及AD早期诊断研究，2022.08-2027.07，在研，子任务单位负责人。
• 上海市青年科技英才扬帆计划项目，基于复杂高维组学数据的疾病预测模型研究，2019.05-2022.04，已结题，主持。

参编教材及专著

• 中国医学教育题库《医学统计学》人民卫生出版社 2022
• 《医学统计学》第4版数字教材 人民卫生出版社 2021
• 《R语言与数据清洗》人民卫生出版社 2019

Research Interests

High Dimensional Data Analysis, Big Data Management and Statistical Inference, Statistical Modeling of Chronic Disease

Education Background

Sep. 2010 ~ Dec. 2016: Ph.D. in Bioinformatics, School of Life Science, Fudan University. Advisor: Li Jin Ph.D.

Aug. 2014 ~ Aug. 2015 Visiting Scholar at School of Public Health, University of Texas, Houston, USA, supported by CSC. Advisor: Momiao Xiong Ph.D.

Sep. 2006 ~ Jun. 2010: Bachelor of Statistics, the National Base Class of Mathematics, School of Mathematics, Shandong University.

Working Experience

• Nov. 2023 ~ Present: Associate Professor, Department of Biostatistics, School of Public Health, Fudan University.
• Jul. 2019~ 2023: Assistant Professor, Department of Biostatistics, School of Public Health, Fudan University.
• Mar. 2017~ 2019: Postdoctoral Researcher, School of Data Science, Fudan University. Advisor: Jianqing Fan Ph.D.

Publications

• Kelin Xu, Wensheng Guo*, Momiao Xiong, Liping Zhu, Li Jin. An Estimating Equation Approach to Dimension Reduction for Longitudinal Data. Biometrika, 2016, 103(1): 189-203.
• Zhenqiu Liu#; Kelin Xu#; Yanfeng Jiang; Ning Cai; Jiahui Fan; Xianhua Mao; Chen Suo; Li Jin; Tiejun Zhang; Xingdong Chen*. Global trend of aetiology-based primary liver cancer incidence from 1990 to 2030: a modelling study. International Journal of Epidemiology, 2021, 50(1): 128-142
• Kelin Xu; Liping Zhu*; Jianqing Fan. Distributed sufficient dimension reduction for heterogeneous massive data. Statistica Sinica, 2022, 32:2455-2476
• Jiacheng Wang, Yi Zheng, Yawen Wang, Chengjun Zhang, Yanfeng Jiang, Chen Suo, Mei Cui, Tiejun Zhang, Xingdong Chen*, Kelin Xu*. BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005-2018. Journal of Translational Medicine, 2023, 21(1):536.
• YiZheng, Jiacheng Wang, Kelin Xu*, Xingdong Chen*. Intake of dietary flavonoids in relation to bone loss among U.S. adults: A promising strategy for improving bone health. Food & Function, 2024, 15,
• Xinming Xu#, Qingying Feng#, Tao Zhang#, Yunlong Gao#, Qu Cheng, Wanqiu Zhang, Qinglong Wu, Ke Xu, Yucan Li, Nhu Nguyen, Diana H. Taft, David A. Mills, Danielle G. Lemay, Weiyun Zhu, Shengyong Mao, Anyun Zhang*, Kelin Xu*, Jinxin Liu*.Infant age inversely correlates with gut carriage of resistance genes, reflecting modifications in microbial carbohydrate metabolism during early life. iMeta, 2024, 3(2):e169.
• Yi Zheng, Ningxin Gao, Yucan Li, Min Fan, Weizhong Tian, Yanfeng Jiang, Yingzhe Wang, Mei Cui, Chen Suo, Tiejun Zhang, Li Jin, Kelin Xu*, Xingdong Chen*.Unraveling the role of serum metabolites in the relationship between plant-based diets and bone health in community-dwelling older adults. Current Research in Food Science, 2024, 8: 100687
• Kelin Xu#, Yingzhe Wang#, Yanfeng Jiang, Yawen Wang, Peixi Li, Heyang Lu, Chen Suo, Ziyu Yuan, Qi Yang, Qiang Dong, Li Jin, Mei Cui*, Xingdong Chen*. Analysis of gait pattern related to cerebral small vessel disease using wearable sensors. Computer Methods and Programs in Biomedicine, 2024, 250:108162.
• Ningxin Gao, Yue Zhuang, Yi Zheng, Yucan Li, Yawen Wang, Sibo Zhu, Min Fan, Weizhong Tian, Yanfeng Jiang, Yingzhe Wang, Mei Cui, Chen Suo, Tiejun Zhang, Li Jin, Xingdong Chen*, Kelin Xu*. Investigating the link between gut microbiome and bone mineral density: The role of genetic factors. Bone, 2024,188:117239.
• Jiaying Li, Hongyu Jia, Zhenqiu Liu, Kelin Xu*. Global, regional and national trends in the burden of low bone mineral density from 1990 to 2030: A Bayesian age-period-cohort modeling study. Bone, 2024,189:117253.
• Yi Zheng, Jincheng Li, Yucan Li, Jiacheng Wang, Chen Suo, Yanfeng Jiang, Li Jin, Kelin Xu*, Xingdong Chen*.  Plasma proteomic profiles reveal proteins and three characteristic patterns associated with osteoporosis: A prospective cohort study. Journal of Advanced Research, 2024,75:491-503
• Yawen Wang, Yi Zheng, Xin Zhang, Jincheng Li, Yucan Li, Chengjun Zhang, Ningxin Gao, Jiacheng Wang, Min Fan, Weizhong Tian, Yanfeng Jiang, Yingzhe Wang, Mei Cui, Chen Suo, Tiejun Zhang, Li Jin, Xingdong Chen*, Kelin Xu*. Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging study. Journal of Functional Foods, 2025, 124:106632.
• Qiu Xiao, Chengjun Zhang, Yanfeng Jiang, Chen Suo, Genming Zhao, Xingdong Chen*, Min Chen*, Kelin Xu*. Identification of subtypes of type 2 diabetes in the Chinese population and their distinct complication risk profiles. Diabetes Obes Metab, 2025 Nov;27(11):6549-6558. doi: 10.1111/dom.70056.
• Yucan Li, Xinming Xu, Yi Zheng, Rui Li, Xin Zhang, Jiacheng Wang, Ningxin Gao, Jianming Wang,Yawen Wang, Jialin Li, Jincheng Li, Danke Wang, Zhenqiu Liu, Mei Cui, Yanfeng Jiang, Yingzhe Wang, Chen Suo, Tiejun Zhang, Kelin Xu*, Xingdong Chen*.Synergistic and heterogeneous aging using composite phenotypes and multiple organ systems aging clocks. Communications Medicine, 2025 Dec 1;5(1):506. doi: 10.1038/s43856-025-01222-w 
• Yucan Li, Xinming Xu, Yi Zheng, Xinyi He, Jiacheng Wang, Zhenqiu Liu, Yanfeng Jiang, Chen Suo, Tiejun Zhang, Xiang Gao, Xingdong Chen*, Kelin Xu*. CardioMetAge estimates cardiometabolic aging and predicts disease outcomes, BMC Medicine, 2026, 24(1): 129  
• Yucan Li#, Xinming Xu#, Raghav Sehgal, Xinyi He, Yi Zheng, Xingdong Chen*, Kelin Xu*. Effect of caloric restriction on organ-specific biological aging in a randomized clinical trial, Clinical Nutrition, 2026, 106625
• Hanhan Zhao, Qiu Xiao, Hao Wang, Yi Zheng, Zhenqiu Liu, Yanfeng Jiang, Chen Suo, Xingdong Chen, Kelin Xu*. Sleep Regularity as a Potentially Modifiable Factor for Osteoporosis Prevention: Interaction With Genetic Susceptibility, Journal of Pineal Research, 2026, 78(3):e70145
• Yi Zheng, Yucan Li, Yawen Gao, Jincheng Li, Chen Suo, Yanfeng Jiang, Li Jin, Kelin Xu*, Xingdong Chen*. Meta-ERS: an exposome-based risk score using non-genetic factors to guide osteoporosis prevention, Journal of Translational Medicine, 2026
• Qiu Xiao#, Yi Zheng#, Hanhan Zhao, Yucan Li, Jianwei Wang, Hao Wang, Chen Suo, Yanfeng Jiang, Xingdong Chen*, Kelin Xu*. Large-Scale Proteomics Uncovers Pre-Disease Inflammation-Lipid Subtypes to Refine Risk Stratification and Prediction of Type 2 Diabetes, Diabetes Obes Metab,
• Yi Zheng#, Yucan Li#, Yawen Gao, Xiao Liang, Jincheng Li, Chen Suo, Yanfeng Jiang, Li Jin, Kelin Xu*, Xingdong Chen*. BHOD: a bone health optimized dietary pattern designed for osteoporosis prevention, NPJ science of food. 2026 Jul 1. doi: 10.1038/s41538-026-00963-9.